by Delthia Ricks , Medical Xpress PD-1 dependent NK cell regulation of CD8+T-cells. C57BL/6 mice were infected with an adenoviral vector encoding the HBV genome and treated with anti-NK1.1 (⍺NK) or isotype control antibody prior to therapeutic vaccination. Intrahepatic lymphocytes were harvested 14 days after immunization. (A) Quantitative real-time PCR analysis of HBsAg mRNA extracted...
by Georgia State University Rationale design of chimeric M2e-H3 stalk protein, purification, and confirmation. A Schematic of full-length HA gene of influenza A virus (A/Aichi/H3N2), and the selective domains as a vaccine target are numbered in amino acid (aa 37-61, 305-338, 1-117) residues. B M2e-H3 stalk vaccine construct with flexible and soluble linker sequences (AAAGGAA; GGGGS;...
by Jacqueline Mitchell, Beth Israel Deaconess Medical Center Omicron Subvariant Mutations and Neutralizing Antibody Responses. Panel A shows the lineage of mutations that have been identified in the omicron BA.1, BA.2, BA.2.12.1, and BA.4 or BA.5 subvariants of SARS-CoV-2, as compared with the reference WA1/2020 isolate. BA.4 and BA.5 have identical sequences of the spike protein...
by Thomas Jefferson University Credit: Pixabay/CC0 Public Domain Colorectal, pancreatic, esophageal and stomach cancers—some of the deadliest kinds of cancer—have high recurrence rates where the cancer comes back even after successful surgery or radiation treatment. To combat these treatment-resistant cancers, Thomas University Jefferson researchers led by Adam Snook, Ph.D., an associate professor of pharmacology and...
OHIO STATE UNIVERSITY COLUMBUS, Ohio – The parasites that cause a disfiguring skin disease affecting about 12 million people globally may have met their match in vaccines developed using CRISPR gene-editing technology, new research suggests. Phase 1 human trials are set to start later this year with a vaccine designed to prevent infection by Leishmania major, the...
The mononucleosis virus, Epstein-Barr, has become a major suspect in the search for what causes multiple sclerosis. Now researchers are raising the next logical question—can we stop both MS and mononucleosis by preventing Epstein-Barr infections, which occur in 95% of adults? Epstein-Barr vaccines currently under development by the U.S. National Institutes of Health (NIH) and the pharmaceutical...
JANUARY 20, 2022 by Yale University Credit: Pixabay/CC0 Public Domain Millions of people around the world have received two shots of Sinovac, a Chinese-manufactured inactive vaccine that is used in 48 countries to help reduce transmission rates of COVID-19. However, those vaccinations alone are of no help against the widely circulating Omicron variant, show a new...
OREGON STATE UNIVERSITY IMAGE: AN OREGON STATE STUDENT SHIELDS HERSELF FROM THE SUN. CREDIT: CELENE CARILLO, OSU CORVALLIS, Ore. – Research by the Oregon State University College of Pharmacy suggests that a vaccine stimulating production of a protein critical to the skin’s antioxidant network could help people bolster their defenses against skin cancer. Ultraviolet radiation...
by Margie Danchin, The Conversation Credit: Shutterstock As Omicron cases soar along Australia’s east coast, many people are faced with having to re-book their vaccination appointments. If you or your child test positive for COVID, you clearly can’t go to the vaccination or booster appointment you had this week. So, when can you go? There...
Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. With new cases of COVID-19 skyrocketing to more than 240,000 a day recently in the U.S., many people are facing the same situation: A family member or friend tests positive or was exposed to someone who did, and the holiday gathering, visit,...
