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Finer touch for tuning stem cell ‘fate’ with substrates of varying stiffness
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Finer touch for tuning stem cell ‘fate’ with substrates of varying stiffness

TOKYO METROPOLITAN UNIVERSITY IMAGE: (top) Intracellular localization of RUNX2 and YAP in MSCs on gelatin gels with different elastic moduli. Notice how more signal is seen in a single location (the nucleus) for stiffer substrates. (bottom) Illustration of how localization of YAP and RUNX2 changes with substrate stiffness for different batches. Note the consistency between...