by Melissa Rohman and Olivia Dimmer, Northwestern University Notch3 deficiency results in vascular dysfunction due to impaired contractility. Immunofluorescence of phosphorylated myosin light chain 2 (pMLC2–red). White arrows highlight alpha-SMA (green), yellow arrows highlight pMLC (red). Credit: Luisa Iruela-Arispe, Ph.D./Northwestern University Decreased activity of a specific signaling pathway in brain vessels was linked to a...