by Vanderbilt University Medical Center Credit: CC0 Public DomainAn international genetic study using multiancestry biobanks has identified novel genetic locations associated with primary open-angle glaucoma (POAG), the most common type of glaucoma and the leading cause of irreversible blindness globally. The findings, published in Cell Reports Medicine, detail ancestry- and sex-specific genetic loci associated with POAG...
Drugs used to treat initial signs of rheumatoid arthritis also improve the early stages of heart disease, according to new research UNIVERSITY OF LEEDS Drugs used to treat initial signs of rheumatoid arthritis also improve the early stages of heart disease, according to new research. Having rheumatoid arthritis (RA) is known to at least double...
A new University of Kentucky College of Medicine study provides insight into how a protein called angiotensinogen (AGT) contributes to blood pressure regulation and atherosclerosis. AGT is a member of the renin-angiotensin system, a hormone system in the human body that regulates blood pressure and fluid balance. AGT produces angiotensin II, which regulates blood pressure...
by University of California, San Francisco Researchers at UC San Francisco have developed a ‘digital biomarker’ that would use a smartphone’s built-in camera to detect Type 2 diabetes—one of the world’s top causes of disease and death—potentially providing a low-cost, in-home alternative to blood draws and clinic-based screening tools. Type 2 diabetes affects more than...
by Massachusetts Eye and Ear Infirmary In a new study of human ear tissues, hearing scientists have demonstrated that age-related hearing loss, also called presbycusis, is mainly caused by damage to hair cells, the sensory cells in the inner ear that transform sound-induced vibrations into the electrical signals that are relayed to the brain by...
by The Ottawa Hospital A Canadian collaboration led by Dr. Baptiste Lacoste has undertaken the first ever in-depth study of vasculature in the autistic brain. Credit: The Ottawa Hospital A Canadian collaboration led by Dr. Baptiste Lacoste has undertaken the first ever in-depth study of vasculature in the autistic brain. The product of four years...
With the growing interest in the accumulation of senescent cells as an important cause of aging, and more funding flowing into this part of the field, researchers are uncovering numerous direct links between cellular senescence and age-related conditions. Senescent cells cause harm to tissues via their inflammatory secretions, the senescence-associated secretory phenotype (SASP). The SASP...
by University of Leeds The blood flow in the surface blood vessels of a mouse that was not treated with M-3. Drugs that were developed to treat Alzheimer’s Disease could be re-purposed to prevent—or even reverse—the damage done to the blood vessels in people who are obese or suffer from type 2 diabetes, according to...
by Centenary Institute Researchers from the Centenary Institute have discovered a potential new therapy for cerebral cavernous malformations (CCMs), a devastating disease that often affects young people and can result in stroke and seizures. Using mouse models, the researchers found that use of the drug, CD5-2 helped normalize the vascular disorders, and inhibited the development...
by Uppsala University Platelets (red) in close contact with tumour vessels (green). Platelets are activated in the tumour microenvironment and secrete a large number of growth factors. Conditional knockout of PDGFB in platelets demonstrates its previously unknown role in pericyte recruitment, maintenance of tumour vascular integrity and host protection against metastasis. Credit: Yanyu Zhang Scientists...
