CHINESE ACADEMY OF SCIENCES HEADQUARTERS Recent evidence suggests a link between cholesterol metabolism and innate immunity. Upon viral infection, macrophages show reduced cholesterol synthesis accompanied by enhanced expression of antiviral genes, including type I interferon (IFN-I). IFN-I can induce 25-hydroxycholesterol (25-HC) accumulation, which blocks viral entry. However, it has been unclear whether other cholesterol-associated metabolic...
Tag: <span>Viral infection</span>
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Tiny capsules packed with gene-editing tools offer alternative to viral delivery of gene therapy
Posted Today New tools for editing genetic code offer hope for new treatments for inherited diseases, some cancers, and even stubborn viral infections. But the typical method for delivering gene therapies to specific tissues in the body can be complicated and may cause troubling side effects. Researchers at the University of Wisconsin–Madison have addressed many...
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What hepatitis C genotypes mean for treatment
By Jenna Fletcher Reviewed by Cameron White, MD, MPH Hepatitis C is liver inflammation that results from a viral infection. It may not cause symptoms, so it can go undetected for years. As the infection progresses over many years, it can cause liver damage. This may take the form of scarring, permanent damage called cirrhosis,...
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How to tell if your upset stomach is a viral infection
An upset stomach can be a result of many things. When symptoms include vomiting, diarrhea and fever, chances are it’s a viral infection. “A viral gastroenteritis, which we sometimes call ‘a stomach bug’ or ‘a stomach flu,” is a common reason for having an acute onset of vomiting and diarrhea, and sometimes with fever,” says Dr. Tina Ardon, a Mayo Clinic family medicine physician. The viral infection is most commonly...
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When the Body Attacks Itself
New research shows how the immune system’s interaction with viruses leads to autoimmune disease Viral infections can trigger the onset of debilitating autoimmune diseases. For example, in acute disseminated encephalomyelitis (ADEM), the body attacks a protein that protects nerves in the brain and spinal cord, often following a viral infection. However, how viral infections interact...
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New Mechanism to Control Human Viral Infections Discovered
CREDIT: CENTERS FOR DISEASE CONTROL AND PREVENTION This image illustrates the beginning stages of an influenza infection and shows what happens after the influenza viruses enter the human body. RIVERSIDE, Calif. (www.ucr.edu) — A team of researchers, co-led by a University of California, Riverside professor, has found a long-sought-after mechanism in human cells that creates...
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