by Quadram Institute SYNOPSIS Non‐canonical functions of the autophagy protein ATG16L1 are mediated by its C‐terminal WD domain. Here, mice expressing WD domain‐lacking ATG16L1 are found to be highly sensitive to influenza virus infection, resulting in cytokine storm and lethal pneumonia. The WD domain of ATG16L1 prevents lethal infection by influenza A virus. Infection is...
