Credit: Pixabay/CC0 Public Domain Mayo Clinic researchers have found that senescent cells—non-dividing “zombie” cells—accumulate in the skin as people age and may influence aging in other parts of the body. Their recent study revealed that transplanting senescent skin cells into a preclinical model revealed that they not only caused that senescence to spread to other...
Tag: <span>Zombie cells</span>
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Drugs that kill ‘zombie’ cells may benefit some older women, but not all, study finds
by Mayo Clinic Credit: CC0 Public Domain Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a “one-size-fits-all” remedy, Mayo Clinic researchers have found. Specifically, these drugs may only benefit people with a high number of senescent cells, according to findings published July 2 in Nature Medicine. Senescent cells...
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Health and zombie cells in aging
Peer-Reviewed Publication MAYO CLINIC With age, cells can experience senescence, a state where they stop growing but continue releasing inflammatory and tissue-degrading molecules. When a person is young, the immune system responds and eliminates senescent cells, often referred to as zombie cells. However, zombie cells linger and contribute to various age-related health problems and diseases....
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Scientists reappraise the role of ‘zombie’ cells that anti-aging medicine has sought to eliminate
by University of California, San Francisco Credit: Pixabay/CC0 Public Domain Not all senescent cells are harmful “zombies” that should be wiped out to prevent age-related disease, according to new research from UC San Francisco, which found that some of them are embedded in young, healthy tissues and promote normal repair from damage. Scientists have now...
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Zombie cells central to the quest for active, vital old age
by LAURA UNGAR This microscope photo provided by the Mayo Clinic in August 2022 shows senescent myoblast cells. Senescent cells resist apoptosis, or programmed cell death, and characteristically get big and flat, with enlarged nuclei. They release a blend of molecules, some of which can trigger inflammation and harm other cells — and paradoxically also...
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Researchers uncover new pathway for accumulation of age-promoting ‘zombie cells’
UNIVERSITY OF PITTSBURGH IMAGE: X-SHAPED CHROMOSOMES ARE STAINED PURPLE, AND TELOMERES APPEAR AS GREEN SPOTS AT CHROMOSOME TIPS. WHEN RESEARCHERS USED A NOVEL TOOL TO INDUCE OXIDATIVE DAMAGE SPECIFICALLY AT TELOMERES, THEY CAN BECOME FRAGILE (GREEN ARROWS), SENDING CELLS INTO SENESCENCE. THE INSET SHOWS AN ENLARGED CHROMOSOME WITH FRAGILE TELOMERES, INDICATED BY MULTIPLE GREEN SPOTS...
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‘Zombie cells’ hold clues to spinal cord injury repair
Mammals have a poor ability to recover after a spinal cord injury which can result in paralysis. The main reason for this is the formation of a complex scar associated with chronic inflammation that produces a cellular microenvironment that blocks tissue repair. Now, a research team led by Leonor Saude, group leader at Instituto de...