| The FDA just approved Alyftrek, a once-daily medicine for a small slice of cystic fibrosis patients that carry certain mutations, including F508del. It’s a triple combination CFTR modulator that works across 31 other mutations, and outperformed Trikafta — another popular Vertex drug for cystic fibrosis — in its ability to reduce sweat chloride levels. This is the company’s fifth CFTR modulator to win U.S. approval.Vertex said that the drug offers simpler dosing for existing patients taking its drugs — but will be beneficial for an additional 150 U.S. patients with the disease, whose mutations are now treatable. |
| cystic fibrosisVertex drug for cystic fibrosis wins approvalThe FDA just approved Alyftrek, a once-daily medicine for a small slice of cystic fibrosis patients that carry certain mutations, including F508del. It’s a triple combination CFTR modulator that works across 31 other mutations, and outperformed Trikafta — another popular Vertex drug for cystic fibrosis — in its ability to reduce sweat chloride levels. This is the company’s fifth CFTR modulator to win U.S. approval.Vertex said that the drug offers simpler dosing for existing patients taking its drugs — but will be beneficial for an additional 150 U.S. patients with the disease, whose mutations are now treatable.glp-1 drugsZepbound approved for sleep apneaThe FDA has approved Eli Lilly’s obesity drug Zepbound, or tirzepatide, as the first medication for moderate-to-severe obstructive sleep apnea. This approval could help expand insurance coverage, including Medicare, which is barred from covering weight-loss drugs. It could also strengthen the case for broader use of GLP-1 treatments, since this is a clear health benefit that isn’t strictly related to weight loss.The studies underpinning this approval showed that Zepbound reduces the breathing interruptions that happen during sleep. Some experts project that Zepbound’s approval could actually reduce the demand for CPAP machines, though others think the devices will still be needed for immediate symptom relief and could be used in tandem with the GLP-1 drug.Read more. |
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