MCMASTER UNIVERSITY Hamilton, ON (Aug. 29, 2021) – A combination therapy of aspirin, statins and at least two blood pressure medications given in fixed doses can slash the risk of fatal cardiovascular disease (CVD) by more than half, says an international study led by Hamilton researchers. The fixed-dose combination (FDC) therapies were examined both with and...
Month: <span>August 2021</span>
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4 in 1 blood pressure pill: Safe and much more effective than usual hypertension treatment
by University of Sydney Credit: Pixabay/CC0 Public Domain High blood pressure is the world’s leading killer but poor rates of blood pressure control remain common. A new strategy where patients are started on a pill containing four medicines, each at a quarter of their usual doses, has been shown to be much more effective in getting...
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Cancer’s ‘Achilles’ heel’ discovered by scientists
by Study Finds VANCOUVER, British Columbia — Scientists may be one step closer to defeating cancer after finding what researchers at the University of British Columbia call the disease’s “Achilles’ heel.” Their study has uncovered a protein that fuels tumors when oxygen levels are low. It enables the cancerous growths to adapt and survive and become more aggressive....
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AstraZeneca hails trial results for COVID treatment
Credit: Unsplash/CC0 Public Domain Drug firm AstraZeneca on Friday announced positive results from a trial of a treatment for COVID-19 symptoms. The drug, made from a combination of two antibodies, was initially developed as a treatment for those who had already been exposed to the disease. A new trial of 5,197 participants who had not been...
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Common pesticide may contribute to global obesity crisis
by McMaster University Credit: CC0 Public Domain A commonly-used pesticide could be partially responsible for the global obesity epidemic, says a study led by McMaster University scientists. Researchers discovered that chlorpyrifos, which is banned for use on foods in Canada but widely sprayed on fruits and vegetables in many other parts of the world, slows down the...
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Aging-US: miRNAs generated from Meg3-Mirg locus are downregulated during aging
IMPACT JOURNALS LLC IMAGE: GENES UPREGULATED IN AGING WHICH ARE TARGETED BY MIRNAS FROM MEG3-MIRG LOCUS. (A) VENN DIAGRAM ILLUSTRATING THE PREDICTED TARGETS OF THE 27 DOWNREGULATED MIRNAS. THREE DATABASES WERE INTERROGATED AND THE OVERLAPPING TARGETS WERE FURTHER USED FOR PATHWAY ENRICHMENT ANALYSIS, WHICH IDENTIFIED 347 UNIQUE GENES. (B) GRAPHICAL ILLUSTRATION OF THE INTERSECTION BETWEEN THE...
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Understanding and targeting prostate cancer metabolism
by Flinders University (A) Two distinct AR siRNAs (siAR (1) and siAR (2); 12.5 nM) reduce the expression of 6PGD at the protein level in LNCaP cells. Cells were transfected with 12.5 nM of each siRNA; after 48 h, proteins were extracted and assessed by Western blotting. (B) siAR (2) reduces the expression of 6PGD mRNA...
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First study to investigate the role of RNA tags in Alzheimer’s disease
by Boston University School of Medicine Credit: Pixabay/CC0 Public Domain Understanding the role of tau protein in Alzheimer’s disease (AD) has led to new ways to diagnose it as well as the creation of medicines now in clinical trials to treat it. Misfolding and aggregation of microtubule associated protein tau (MAPT) are core features of AD....
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Ultrasound detects ulcerative colitis disease activity
(HealthDay)—A new ulcerative colitis intestinal ultrasound (UC-IUS) index shows strong correlation with endoscopy for detection of disease activity, according to a study published in the August issue of the Journal of Crohn’s and Colitis. Steven Bots, M.D., from the Amsterdam University Medical Center, and colleagues developed an ultrasonographic activity index using endoscopy as the reference standard (evaluation of 207 colonic...
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Cognitive remediation benefits patients with schizophrenia
(HealthDay)—Cognitive remediation is effective for both cognitive and functional outcomes among patients with schizophrenia, according to a systematic review and meta-analysis published in the August issue of JAMA Psychiatry. Antonio Vita, M.D., Ph.D., from the University of Brescia in Italy, and colleagues conducted a systematic literature review to identify randomized clinical trials comparing cognitive remediation to any other...