Anti-cancer drugs could prevent the build-up of fatty plaques in blood vessels which cause heart attack and stroke, a new study by the University of Sheffield has shown. The new research, funded by the British Heart Foundation, suggests drugs which are already in clinical trials for the treatment of cancers could be repurposed to prevent atherosclerosis –...
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Diabetes researchers discover potential new insulin sensitizers
Potential drug lowered blood sugar without triggering fat storage in mice New York, NY (October 24, 2017)–A root cause of type 2 diabetes is a condition known as insulin resistance, in which cells stop responding to commands from the hormone that regulates glucose (sugar) storage. Restoring insulin sensitivity can be an effective strategy for preventing...
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Tarloxitinib puts tumor-seeking tail on anti-EGFR drug to precisely target lung cancer
EGFR is a common genetic target in lung cancer, but not all EGFR mutations are created equal. Patients with a type of EGFR anomaly called an “EGFR exon 20 insertion” often fail to respond to existing drugs targeting EGFR. Previous work shows this is because it simply takes a much higher concentration of anti-EGFR drugs...
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A non-invasive computational imaging approach may predict response to immunotherapy
A computational imaging-based signature of immune-cell infiltration in and around a tumor could predict patients’ responses to treatment with anti-PD1/PDL1 immunotherapies, according to data from a study presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 26-30. “Immunotherapy, a recent modality of treatment in oncology, has profoundly changed the management...
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Scientists discover surprising immune cell activity that may be limiting immunotherapy
Researchers have uncovered a surprising process within a key immune cell that may help explain the limitations of immunotherapy as a cancer treatment. Treg cells work within the immune system to suppress immune function. It’s a normal process: T cells fight an infection and when the threat is over, Treg cells send the signal to stand...
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Researchers reveal the role of a DNA repair mechanism
Fernando Gómez Herreros and his research team. Researchers from the University of Seville, in collaboration with the Genome Damage and Stability Centre of the University of Sussex in the United Kingdom, have recently published a study in the review Nature Communications, in which they make an important step forward in understanding more exactly what the...
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RNA Editing Possible with CRISPR-Cas13
Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells. WIKIMEDIA, NICOLLE RAGER, NATIONAL SCIENCE FOUNDATION Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called RNA Editing for Programmable A-to-I replacement (REPAIR),...
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RNA Editing Possible with CRISPR-Cas13
Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells. Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called RNA Editing for Programmable A-to-I replacement (REPAIR), is described today (October 25)...
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Immunotherapy with peptides
Abstract Specific allergen immunotherapy is clinically effective and disease modifying. It has a duration of effect that exceeds the treatment period and prevents both the progression of allergic rhinitis to asthma and the acquisition of new allergic sensitizations. However, immunotherapy is associated with a high frequency of adverse events related to the allergenicity of vaccines....
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Details uncovered in development of immune cell implicated in cancer, autoimmune diseases
While the immune system is critical for fighting off invading micro-organisms, sometimes it can turn against the body and attack healthy tissues or be involved in cancer cell growth. A study by University of North Carolina Lineberger Comprehensive Cancer Center researchers provides new details about the development of a particular immune cell that can play...