by University of California, Irvine During lung cancer progression and the corresponding development of cachexia, circadian control of glucose production is disrupted, resulting in increased levels of glucose from the liver. These findings illustrate tissue-tissue crosstalk whereby a lung tumor can disrupt the circadian metabolism of a distal tissue, potentially for its own growth advantage. Credit:...
by University of Cambridge A team of engineers and clinicians has developed an ultra-thin, inflatable device that can be used to treat the most severe forms of pain without the need for invasive surgery. The device, developed by researchers at the University of Cambridge, uses a combination of soft robotic fabrication techniques, ultra-thin electronics, and microfluidics....
by Delthia Ricks , Medical Xpress Credit: CC0 Public Domain Quick, accurate, and easy-to-use, CRISPR-Cas9 has made genomic editing more efficient—but at the same time has made human germline editing much more feasible, erasing many of the ethical barriers erected to prevent scientists from editing the genes of heredity. “The ethical debate about what is...
by Amy Colgan, The Ohio State University Fig. 1: In vitro studies of mdx4cv mutation correction using ABE-NG. From: Efficient precise in vivo base editing in adult dystrophic mice a Genomic DNA, encoded amino acids and guide RNA with PAM (highlighted in blue) sequences at the stop codon mutation site (red). b The reporter construct contains...
by Anna Jones, University of Alabama at Birmingham Investigations by researchers at UAB reveal the existence of a day-night rhythm of heart hormones, and how the disturbance of this rhythm could contribute to a high risk of high blood pressure and poor cardiovascular health in obese individuals. Credit: University of Alabama at Birmingham A series of studies recently...
by Liu Jia, Chinese Academy of Sciences A scanning electron microscope micrograph depicting a mass of Yersinia pestis bacteria in the foregut of an infected flea. Credit: Wikipedia Multiple strategies have been employed by pathogenic bacteria to sabotage host innate immune signaling to facilitate their infection. Previous studies revealed that the Yersinia effector protein YopJ targets and inhibits...
The SARS-CoV-2 virus contains a gene that codes for a strange protein that could be a good target for drugs to fight COVID-19 and possibly other coronavirus infections, according to a new study from the University of California, Berkeley. When the virus injects its genome into a cell, the so-called ORF3a gene is expressed to...
NIH/NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE IMAGE: In a study of Drosophila fruit flies, NIH scientists found that only about 30% of the genes that are hallmarks for aging may set an animal’s internal clock. The rest may reflect the body’s response to bacteria. Above is a picture of a Drosophila gut, a key source of bacteria....
Thanks to researchers in different fields who put in nearly two decades of past work on mRNA vaccine technology, people around the world are being immunized today from COVID-19 — and hopefully leading us out of this pandemic. Now, because of the increased focus on this versatile technology and that foundation of research, mRNA vaccines for other diseases have...
GOETHE UNIVERSITY FRANKFURT FRANKFURT. Cancer and many other diseases are based on genetic defects. The body can often compensate for the defect of one gene; it is only the combination of several genetic errors that leads to the clinical picture. The 3Cs multiplex technique based on CRISPR-Cas technology developed at Goethe University Frankfurt now offers...
