Using a mouse model of painful osteoarthritis, they found that blocking this pathway eliminates pain associated with osteoarthritis (OA) and results in a return to normal limb use. The work, the first to find an association between this pathway and osteoarthritis pain, could lead to the development of new, effective pain treatments for people with...
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Pancreatic cancer cells feed off hyaluronic acid
Often found in beauty products and wellness supplements, hyaluronic acid attracts and retains water well. It’s also a major player in the physiology of pancreatic tumors. Hyaluronic acid, or HA, is a known presence in pancreatic tumors, but a new study from researchers at the University of Michigan Health Rogel Cancer Center shows that hyaluronic acid also acts...
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Eye movements and machine learning reveal signs of illness
DTU machine learning algorithm analyzes patterns in eye movements in patients with neurological and psychiatric disorders and helps in diagnosis. The ability to make eye contact with other people is an important part of our social interaction with each other. Among other things, we read joy, trust, and interest through eye contact, but we also look at...
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Researchers produce a cellular blueprint of COPD
Chronic Obstructive Pulmonary Disease, or COPD, is the third leading cause of death worldwide. Yet despite its prevalence, the disease is not well understood on a cellular level. New Yale research has provided an unprecedented atlas of the cells in the COPD-afflicted lung, identifying those cells and pathways that may contribute to the reduced lung...
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Rethinking Cerebral Palsy Origins
Study uncovers genetic causes in up to one quarter of patients. Cerebral palsy, or CP, has widely been viewed as the result of perinatal oxygen deprivation or other birth-related factors like prematurity. “In CP, the first thing that comes to many physicians’ minds is birth injury or asphyxia,” said Siddharth Srivastava, assistant professor of neurology at Harvard Medical...
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Study: Why are PPIs underused for the prevention of gastrointestinal bleeding?
Gastrointestinal bleeding is a potentially life-threatening condition. It is often linked to the use of medications like non-steroidal anti-inflammatory drugs, or NSAIDS, like ibuprofen and naproxen, aspirin and blood thinners. “Many of these drugs are prescribed to individuals who have heart disease,” said Jacob E. Kurlander, M.D., M.S., an assistant professor and gastroenterologist at Michigan Medicine and...
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New genetic clues on multiple sclerosis risk
An international team of researchers led by Karolinska Institutet in Sweden have discovered that a cell type in the central nervous system known as oligodendrocytes might have a different role in the development of multiple sclerosis (MS) than previously thought. The findings, published in the journal Neuron, could open for new therapeutical approaches to MS. MS is...
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CNIO researchers identify drugs potentially capable of reducing the mortality of COVID-19
CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) Inflammation is a defence mechanism of the body to fight pathogens. However, when it is widespread and excessive, it can aggravate the pathology and even cause death. One of the ways in which this excessive response occurs is called acytokine storm, an inflammatory process produced by these proteins, cytokines,...
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New commentary in European Journal of Clinical Nutrition makes case for adopting ‘blue zone’ diet to stave off COVID-19
PHYSICIANS COMMITTEE FOR RESPONSIBLE MEDICINE WASHINGTON, D.C.—As the Omicron variant continues to cause a record number of infections, a new commentary in the European Journal of Clinical Nutrition is calling for people to adopt a plant-based diet, which research shows can help reduce the risk of severe COVID-19 and mortality. “It represents the most cost-effective approach and should be...
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How a hyperactive cell in the brain might trigger Alzheimer’s disease
It all started with genetic data. A gene here, a gene there. Eventually the story became clearer: If scientists are to one day find a cure for Alzheimer’s disease, they should look to the immune system. Over the past couple decades, researchers have identified numerous genes involved in various immune system functions that may also...