by Patrick Lejtenyi, Concordia University Credit: Pixabay/CC0 Public Domain It’s a commonly heard question after New Year’s [celebrations]: “Why do we drink the way we do?” A group of researchers has found that at least some of it has to do with a particular protein in the part of the forebrain that regulates, among other...
Jolting the brain’s circuits with electricity is moving from radical to almost mainstream therapy. Some crucial hurdles remain
By Isabella Cueto Jan. 12, 2022 Kevin O’Neill, seen in the backyard of his San Anselmo, Calif., home, is being treated with deep brain stimulation for Parkinson’s disease.CONSTANZA HEVIA FOR STAT In June 2015, biology professor Colleen Hanlon went to a conference on drug dependence. As she met other researchers and wandered around a glitzy...
Deleting specific gene in male mice reduces fat mass
JANUARY 11, 2022 by Max Martin, University of Western Ontario PhD candidate Brent Wakefield led a breakthrough study that could be crucial in addressing obesity. Credit: Max Martin/Western Communications It sounds too good to be true: blocking a gene linked to obesity to trigger a major reduction in body fat. While it’s not a reality for...
Changemaker Senp5: New protein isoform with crucial role in brain development
JANUARY 11, 2022 by Waseda University The newly discovered Senp5S protein helps regulate “mitochondrial dynamics” that is crucial for the differentiation of neurons during brain development. Credit: Waseda University Understanding how the brain develops is crucial to formulating treatments and management protocols for a variety of developmental disorders, as well as degenerative neurological diseases. Right from...
Obscure protein is spotlighted in fight against leukemia
JANUARY 11, 2022 by Cold Spring Harbor Laboratory Former Cold Spring Harbor Laboratory (CSHL) graduate student Sofya Polyanskaya in the lab of CSHL Professor Christopher Vakoc. Credit: CSHL/2018 Acute myeloid leukemia (AML) is an aggressive cancer of white blood cells with few effective targeted therapies available to treat it. Cold Spring Harbor Laboratory (CSHL) Professor Christopher...
Boosting one gene in the brain’s helper cells slows Alzheimer’s progression in mice
JANUARY 11, 2022 by Eric Hamilton, University of Wisconsin-Madison Fig. 1: Changes to the astrocyte translatome due to tau and amyloid pathology. A Schematic illustrating the crossing of MAPTP301S with the Aldh1l1_eGFP-RPL10a mouse. Astrocyte TRAP-seq performed on MAPTP301S vs. WT mice (both carrying the Aldh1l1_eGFP-RPL10a allele) at 3 months (B) and 5 months (C) in the spinal cord....
How does excess sugar affect the developing brain throughout childhood and adolescence?
JANUARY 11, 2022 by Lina Begdache, The Conversation Credit: Unsplash/CC0 Public Domain Parents often stress about their kids’ sugar intake, but it can be hard to know how much is too much—or what to do about it. Glucose—a simple sugar that forms the basis of most carbohydrate-rich food—is the primary source of energy for the brain....
How to remain youthful and resilient despite stress
JANUARY 11, 2022 by Jolanta Burke, Padraic J. Dunne, The Conversation Credit: Obak/Shutterstock A bit of stress can be good for your mental and physical wellbeing, but too much can lead to anxiety, depression and other health problems. It can also make you age faster. So learning to become more stress-resilient is important if you’re not...
CMS to restrict coverage of Biogen’s controversial Alzheimer’s drug to only clinical trials
by ZACHARY BRENNAN CMS on Tuesday said it will only pay for Biogen’s Aduhelm and other FDA-approved anti-amyloid monoclonal antibodies for Alzheimer’s disease under CMS-approved randomized controlled trials. In a draft national coverage decision, which insurers nationwide are likely to follow, CMS said it’ll be looking for randomized controlled trials that “demonstrate a clinically meaningful benefit in cognition...
Older adult opioid overdose death rates on the rise
JANUARY 11, 2022 by Northwestern University Credit: CC0 Public Domain A common stereotype for an “older adult” might include early-bird specials, dentures and tickets to the matinee show. A new Northwestern Medicine study that analyzed 20 years of fatal opioid overdose data in adults 55 and older paints a much different picture. Between 1999 and 2019, opioid-related...