by Karolinska Institutet Dietary change leading to weight loss normalizes T2D-induced neuroinflammatory changes after tMCAO. a Iba-1 expression in striatum after sham surgery. b Iba-1 expression in contralateral striatum after tMCAO surgery. c Iba-1 expression in ipsilateral striatum after tMCAO surgery. d CD68 expression in ipsilateral striatum after tMCAO surgery. Data are presented as mean ± SD....
by Brigham and Women’s Hospital Credit: Unsplash/CC0 Public Domain Imagine going to the doctor’s office at age 55 and, after measuring a set of health variables, the physician predicted your health trajectory for 10 years into the future. Investigators from Brigham and Women’s Hospital studied easily obtained variables among women at midlife, variables included health...
by Bob Yirka, Medical Xpress Fig. 1: Psychological stress promotes the expansion of ileal Enterobacteriaceae. a Schematic representation of the stress protocol and legend of bacterial phylum and family. Taxonomy plots of 16S rRNA sequencing of the ileal (b), cecal (c), or colonic (d), contents of naive (n = 4), starved (food and water deprived, n = 4), and...
by Mark Blackwell Thomas, Florida State University Preference for social novelty behaviors were similar in OXTRAvil WT and KO males and females. OXTRAvil mice displayed a preference for social novelty—a preference for a tower holding a novel stranger mouse (stranger tower; gray markers) over a tower holding a familiar mouse (familiar tower; white markers)—as evident by increased...
by Trinity College Dublin MNDA regulates dsRNA- and virus-stimulated IFNα induction in monocytes. a, b Quantitative PCR analysis of IFNα (a) and IFNβ (b) mRNA from THP-1 cells expressing control or MNDA shRNA transfected with poly(I:C) (2.5 μg/ml) for the indicated times. c, d Release of IFNα protein from THP-1 cells expressing control or MNDA shRNA...
Here, Emily Landon, infectious disease expert and executive medical director for infection prevention and control at University of Chicago Medicine, answers common questions about COVID-19 tests. These include when to get a COVID-19 test, what kind you should use, what to do if you can’t get one at all, and why it’s still important to get...
Sepsis is a state of runaway inflammation in response to infection, a condition that is more serious and more often fatal in older individuals. With age, the immune system becomes every more overactive and inflammatory, reacting to signals created by the damaged environment of the body. This background of chronic inflammation makes it ever less likely that...
People walk differently. Your way of walking is not exactly as unique as your fingerprints, but it is recognizably yours. And now an international team of scientists say that the way we walk may predict our osteoarthritis risk in the future. The way you walk is relatively unique and causes different kinds of stress to...
Scientists have discovered an antibody that may lead to more effective treatments against a wide range of sarbecoviruses, the family of viruses that includes the coronavirus SARS-CoV-2 and their variants. The antibody neutralizes SARS-CoV-2, SARS-CoV-2 variants and other sarbecoviruses in the lab, protects against infection in animal studies, and appears to be able to thwart...
GEORGIA INSTITUTE OF TECHNOLOGY IMAGE: RENDERING OF BRAIN/NEURONS FIRING (NIH) CREDIT: NIH Severe and persistent disability often undermines the life-saving benefits of cancer treatment. Pain and fatigue — together with sensory, motor, and cognitive disorders — are chief among the constellation of side effects that occur with the platinum-based agents used widely in chemotherapy treatments...
