by Perelman School of Medicine at the University of Pennsylvania Credit: CC0 Public Domain An experimental immunotherapy can temporarily reprogram patients’ immune cells to attack a specific target via only a single injection of messenger RNA (mRNA), similar to the mRNA-based COVID-19 vaccines, according to a new study from researchers in the Perelman School of...
Risk of overactive bladder associated with medications for dementia
by University of Houston Credit: Unsplash/CC0 Public Domain A study from the University of Houston College of Pharmacy, published in the Journal of the American Geriatrics Society, has evaluated the risk of overactive bladder (OAB) as a side effect of cholinesterase inhibitor (ChEI) drugs taken for dementia and Alzheimer’s disease. The research was based on the dissertation...
Anxiety and PTSD linked to increased myelin in brain’s gray matter
by University of California – Berkeley An fMRI scan of the brain of a military veteran with PTSD, showing gray matter regions with increased myelin. Credit: UCSF / Linda Chao A recent study links anxiety behavior in rats, as well as post traumatic stress disorder (PTSD) in military veterans, to increased myelin—a substance that expedites...
Innovative approach brings cell-reprogramming therapy for heart failure closer to reality
by Ana María Rodríguez, Ph.D., Baylor College of Medicine Using endothelial cell plasticity to improve fibroblast reprograming efficiency. Credit: The authors / Scott Holmes, C.M.I. Not too long ago, the idea of taking—for instance—a skin cell and transforming it into a muscle cell was unthinkable. About 10 years ago, however, revolutionary research showed that it...
Potential New Gene Editing Tools Uncovered
Few developments have rocked the biotechnology world or generated as much buzz as the discovery of CRISPR-Cas systems, a breakthrough in gene editing recognized in 2020 with a Nobel Prize. But these systems that naturally occur in bacteria are limited because they can make only small tweaks to genes. In recent years, scientists discovered a...
New resistance-busting antibiotic combination could extend the use of ‘last-resort’ antibiotics
Scientists have discovered a new potential treatment that has the ability to reverse antibiotic resistance in bacteria that cause conditions such as sepsis, pneumonia, and urinary tract infections. Carbapenems, such as meropenem, are a group of vital often ‘last-resort’ antibiotics used to treat serious, multi-drug resistant infections when other antibiotics, such as penicillin, have failed. But some...
Long-Reads and Powerful Algorithms Identify “Invisible” Microbes
New technique developed by international research team could provide tremendous insights into health and disease through the use of powerful algorithms. Microbes are everywhere – in our guts, on our skin, permeating the environments around us. Studying these microbial communities has delivered tremendous insights into disease and good health, but identifying all the distinct species in...
Finger Clip for Blood Pressure Monitoring
JANUARY 5TH, 2022 CONN HASTINGS ANESTHESIOLOGY, CARDIOLOGY, CRITICAL CARE, MEDICINE At the University of Missouri a team of researchers developed a custom finger clip device that can continuously measure a variety of vitals, including blood pressure. The novel device represents a new way to measure vitals, and contains two commercial photoplethysmography (PPG) sensors that operate...
mRNA vaccine makers set sights on shingles and the Epstein-Barr virus
By Rich Haridy January 05, 2022 As Moderna works on a mRNA vaccine against the Epstein-Barr virus, Pfizer sets its mRNA sights on a shingles vaccineMattLphotography/Depositphotos More advances on the mRNA vaccine front this week as both Pfizer and Moderna move forward on new viral targets for future vaccines. Pfizer is turning its focus to...
Marijuana users’ risk of deadly complication doubles after rare type of bleeding stroke
AMERICAN HEART ASSOCIATION Embargoed until 4 a.m. CT/5 a.m. ET Thursday, Jan. 6, 2022 DALLAS, Jan. 6, 2022 — Among people with an aneurysmal subarachnoid hemorrhage (aSAH) stroke, a type of bleeding stroke, recent marijuana users were more than twice as likely to develop a dangerous complication that can result in death or greater disability, according to new...