by Mary Ann Liebert, Inc (A) Linear correlation between the HA concentration used in the cross-linking reaction and the final HA amount in the hybrid GE:PLLA 1:1 scaffolds. When using a concentration >0.025% w/v, HA was not soluble anymore and a plateau is reached. (B–G) SEM images at different magnifications of the electrospun cross-linked hybrid...
by Leigh MacMillan, Vanderbilt University Credit: Pixabay/CC0 Public Domain Patients with autoimmune diseases such as systemic lupus erythematosus (SLE) have higher blood levels of the protein S100A9, but the source of this protein has not been identified. Andrew Monteith, Ph.D., Eric Skaar, Ph.D., MPH, and colleagues reasoned that high S100A9 may reflect increased levels of...
by University of Birmingham Immune reconstitution following CD20 depletion and vaccine responsiveness. (A) Time between last administration of anti-CD20 B-cell-depleting treatment and vaccine administration (left panel—haemato-oncology patients [red], right panel—rheumatology patients [blue]). (B) Seropositivity following SARS-CoV-2 vaccination with respect to time from last administration of anti-CD20 B-cell depletion. (C) Association between the magnitude of antibody...
by Lynn Shea, Carnegie Mellon University Credit: Carnegie Mellon University Athletes and sports fans know that a torn ACL knocks a player out of the game, requires surgical repair and involves a long recovery. But for many injured athletes, being temporarily sidelined is only the beginning of a lifelong struggle. According to Eni Halilaj, an...
By MIKE STOBBE NEW YORK (AP) — Emerging reports show that two little-known drugs are making lethal new contributions to America’s drug overdose crisis. Para-fluorofentanyl and metonitazene are being seen more often by medical examiners looking into overdose deaths, according to a government report published Thursday. They often are taken with — or mixed with...
Two researchers from Skoltech and McGill University have published a review of the promising research field known as structural proteomics in the influential journal Chemical Reviews. This field combines protein chemistry and mass spectrometry, an advanced analytical technique for identifying the chemical composition of substances based on precise mass. The ultimate goal is to resolve the detailed structure of...
POHANG UNIVERSITY OF SCIENCE & TECHNOLOGY (POSTECH) IMAGE: A) SCHEMATIC DIAGRAM OF A REDOX-TRIGGERED SELF-IMMOLATIVE NITRIC OXIDE PRODRUG AND ITS APPLICATION (CONJUGATION WITH A CARRIER), AND THE PRINCIPLE OF REDOX-TRIGGERED SELF-IMMOLATIVE FRAGMENTATION. B) SCHEMATIC OF THE LYMPHATIC DELIVERY AND TREATMENT PROCESS OF REDUCTIVE NITRIC OXIDE PRODRUGS FOR THE TREATMENT OF METASTATIC CANCER. CREDIT: POSTECH Assassins...
PUSAN NATIONAL UNIVERSITY IMAGE: SCIENTISTS CONDUCT AN UPDATED ANALYSIS TO CLARIFY IF ALCOHOL DRINKERS MAY BE AT HIGHER RISK OF DEVELOPING EPILEPSY AND UNPROVOKED SEIZURES CREDIT: PUSAN NATIONAL UNIVERSITY Epilepsy, a common neurological disorder associated with stigma, psychiatric comorbidities, and rising healthcare costs, affects approximately 50 million people globally. A common risk factor associated with...
by Amy Norton (HealthDay)—Finding the right medication for rheumatoid arthritis isn’t easy, and a newer pill against the disease carries higher risks of heart attack, stroke and cancer than older RA drugs, a new clinical trial confirms. The study was mandated by the U.S. Food and Drug Administration after earlier safety signals about the drug, called...
by American Physiological Society Myocardial glucose uptake results. A: representative [18F]FDG PET/CT vertical long axis images showing Ki of the heart after secretin and placebo infusions (n = 1). Short axis images are shown in Supplemental Fig. S1. (see https://doi.org/10.6084/m9.figshare.16912807). B: the effect of secretin infusion on myocardial glucose uptake compared with placebo (n = 15)....
