July 25, 2024 by Tsinghua University Press Abnormal microglial energy metabolism in AD. Translocation of Aβ into microglial mitochondria by the outer membrane translocase (TOM) impairs mitochondrial function and inhibits phagocytosis. TREM2 promotes gene expression of the transcription factor HIF1α and mTOR signaling, but inhibits p38/MAPK signaling and glycolysis in microglia. TPSO inhibits the activation...
By Chris Melore Research led by Dr. Rene Frank, University of Leeds Jul 11, 2024 Left, fluorescence image of amyloid in cryo-preserved post-mortem human brain. Middle, 3-dimensional molecular architecture of β-amyloid plaque. Right, in-tissue structure of tau filaments within post-mortem brain. (CREDIT: University of Leeds) LEEDS, United Kingdom — In a world-first achievement, scientists are...
Medscape Medical News Megan Brooks June 27, 2024 Alzheimer’s disease (AD) is highly heritable, and previous research suggests a preferential maternal inheritance of AD. New data confirm this hypothesis but also highlight the importance of considering family history in both parents. In a large cohort of cognitively normal older adults, a family history of memory...
by Florida Atlantic University Mahmoud Seifallahi (seated) and Behnaz Ghoraani, Ph.D., reviewing walking performance using a depth camera, which can detect and track 25 joints of body movement. Credit: Florida Atlantic UniversityA first-of-its-kind study suggests that to detect subtle gait impairments in older adults that often are prevalent in the early stages of cognitive decline,...
by University of Technology, Sydney A working model on the biological effects of air pollutant particulates in the early onset pathologies of AD. Credit: Environment International (2024). DOI: 10.1016/j.envint.2024.108512Magnetite, a tiny particle found in air pollution, can induce signs and symptoms of Alzheimer’s disease, new research suggests. Alzheimer’s disease, a type of dementia, leads to memory...
by University College London Credit: Pixabay/CC0 Public DomainPeople at risk of Alzheimer’s disease have impaired spatial navigation prior to problems with other cognitive functions, including memory, finds a new study led by UCL researchers. The research, published in Alzheimer’s & Dementia, used virtual reality to test the spatial navigation of 100 asymptomatic midlife adults, aged 43-66,...
by Rutgers University Credit: Pixabay/CC0 Public DomainThe impact of abdominal fat on brain health and cognition is generally more pronounced in middle-aged men at high risk of Alzheimer’s disease than in women, according to researchers at Rutgers Health. In middle-aged individuals with a family history of Alzheimer’s disease, the amount of fat in their abdominal organs...
by University of North Carolina at Chapel Hill Chirality inversion mechanisms. Scheme and TEM images (a) of Fmoc-FFFF-PEG2 prepared at RT, or heated to 37 and 40 °C to track the chirality inversion (50 nm scale bars). Schematic (b) of seeded growth via right-handed nucleation points. CD spectra (c) of nucleated assemblies grown with varying monomer:seed ratios. TEM...
by Lauran Neergaard A closeup of a human brain affected by Alzheimer’s disease, is displayed at the Museum of Neuroanatomy at the University at Buffalo in Buffalo, N.Y., on Oct. 7, 2003. According to findings published Wednesday, Feb. 21, 2024 in the New England Journal of Medicine, Alzheimer’s quietly ravages the brain long before symptoms...
by Hong Kong University of Science and Technology The research team has developed a revolutionary blood test for Alzheimer’s disease (AD) that can measure the levels of 21 proteins in multiple crucial biological pathways. The test can also calculate an AD risk score, enabling the evaluation of an individual’s AD status. Credit: Hong Kong University of...
