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Gene therapy relieves back pain, repairs damaged disc in mice

NEWS RELEASE 16-MAY-2024 Study suggests nanocarriers loaded with DNA could replace opioids Peer-Reviewed PublicationOHIO STATE UNIVERSITY COLUMBUS, Ohio – Disc-related back pain may one day meet its therapeutic match: gene therapy delivered by naturally derived nanocarriers that, a new study shows, repairs damaged discs in the spine and lowers pain symptoms in mice. Scientists engineered nanocarriers...

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What factors predict when older adults will stop driving?

by American Academy of Neurology Credit: Pixabay/CC0 Public Domain What factors lead older adults to stop driving? A new study followed older adults who had no memory or thinking problems to examine this question. The study is published in the May 22 online issue of Neurology. “Alzheimer’s disease develops over a long time—people may have...

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Taking A Close Look At The Science Behind Infrared Saunas

Infrared saunas have become increasingly popular in Australia in recent years. But what exactly are they, and what are the scientific explanations behind their touted health benefits? Let’s take a close look at the science behind infrared saunas. How Infrared Saunas WorkUnlike traditional saunas which use heat to warm the air, infrared saunas use light...

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Is a 1-Hour Glucose Test Better at Predicting T2D Risk?

Miriam E. Tucker A new position statement from the International Diabetes Federation advises using a 1-hour 75-g oral glucose tolerance test (OGTT) to improve identification of people at risk of developing type 2 diabetes. “There are many, many people who may appear ‘normal’ if you use A1c or fasting glucose, but if you do a...

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Physician advises diabetics to heed FDA’s smart device warning

by New York Institute of Technology Credit: Pixabay/CC0 Public DomainThe FDA has warned diabetes patients not to use smartwatches or smart rings to measure their blood glucose levels. Now, obesity medicine expert Eleanor Yusupov, D.O., assistant professor at New York Institute of Technology College of Osteopathic Medicine, is sharing insight for these patients. While many...

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4 in 10 Patients Recall Hidden Consciousness After Near-Death Experiences, Study Finds

While in extended CPR during cardiac arrest, patients showed no outward signs of consciousness—but scientists did record brain activity in those individuals. BY CAROLINE DELBERTlightning hitting a brain from the top against a dark cloudlike background Getty ImagesA landmark study reports the brain activity of patients in extended CPR during cardiac arrest.Patients showed no outward...

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Baseline findings among hospitalized mucormycosis patients: A multicentric ambispective cohort study in India

by Tsinghua University Press Directed acyclic graph demonstrating the relationship between potential risk factors of mortality due to mucormycosis. Credit: Dr. Rizwan Suliankatchi Abdulkader, Indian Council of Medical ResearchMucormycosis is a relatively rare but serious fungal infection increasingly recognized for its poor prognosis and high mortality. Due to the COVID-19 pandemic, the incidence of mucormycosis...

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Higher Weight Loss on Tirzepatide Links to Seven Factors

Mitchel L. Zoler, PhD October 26, 2023 TOPLINE: Among the 3188 people with type 2 diabetes who were adherent to their tirzepatide (Mounjaro, Lilly) regimen in four pivotal trials of the agent, a quarter achieved at least a 15% cut from their baseline body weight after 40–42 weeks of treatment, and researchers found seven baseline variables that...

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UiB researchers solve protein mystery

Peer-Reviewed Publication THE UNIVERSITY OF BERGEN IMAGE: FIGURE 1: N-TERMINAL ACETYLATION BY NATC SHIELDS PROTEINS FROM DEGRADATION. (LEFT) THE NATC COMPLEX ACETYLATES PROTEINS HARBORING A HYDROPHOBIC RESIDUE IN THE SECOND POSITION (MΦ). FOLLOWING NT-ACETYLATION, AC-UBE2M AND AC-UBE2F PROMOTE CULLIN NEDDYLATION (N8), RESULTING IN UBIQUITYLATION (UB) AND PROTEASOMAL DEGRADATION OF TARGETED CULLIN SUBSTRATES, AC-ARFRP1 IS TARGETED...