Aging is considered to be synonymous with the appearance of major diseases and an overall decline in physical and mental performance. This mini-review summarizes the main findings on nutraceuticals that are believed to slow aging processes by delaying and even preventing the development of multiple chronic diseases. These nutraceuticals may help improve productivity and quality of life in the elderly. Researchers from Migal-Galilee Research Institute (Israel), University of Ljubljana (Slovenia) and University of Belgrade (Serbia) have contributed their review after conducting a literature review work published on of nutraceuticals. The research found that the most robust environmental manipulation for extending lifespan is caloric restriction without malnutrition. Some nutraceuticals can mimic caloric restriction effects. Caloric restriction is well established as a strategy to extend lifespan without malnutrition. A variety of nutraceuticals were reported to mimic the effect of caloric restriction by modulating the activity of insulin-like growth factor 1 receptor signaling and sirtuin activity and consequently promote longevity. The review, published in Current Nutraceuticals, offers a special focus on the nutraceuticals that impact insulin-like growth factor 1 receptor signaling and sirtuin activity in mediating longevity and healthspan.

Keywords: Nutraceuticals, longevity, caloric restriction, insulin-like growth factor 1 receptor (IGF1R), silent mating type information regulation 2 homology 1 (SIRT1)

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