Plasmacytoid dendritic cells (pDCs) are a rare type of immune cells that secrete large quantities of type 1 interferon (I-IFN), a key driver of immunity to infectious invaders and cancer. However, the mechanisms that control the I-IFN secretion are still poorly understood. Researchers from Eindhoven University of Technology and Radboud University Nijmegen have developed a groundbreaking, high-throughput lab device to speed up the research. Remarkably, they discovered that only a very small fraction of single pDCs produce I-IFN and is responsible for the onset of immunity. The results are published in Nature Communications this week.
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