by Monash University Human LAG-3 homodimer (with domains D1, D2, D3 and D4) binding to two separate HLA-II (MHC-II) molecules on the surface of an antigen-presenting cell (APC), imposing a distinct 38° offset angle. This figure has been modified from the original figure 1c of Petersen et al to aid visualization. Credit: Monash University Australian-led research...
Tag: <span>Cancer Immunotherapy</span>
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Opioids interfere with cancer immunotherapy, but another type of drug could help
by University of Pittsburgh Credit: Etatics Inc. from Pexels Opioids are often first-line treatments for cancer-related pain, but they can suppress the immune system and reduce the effectiveness of immunotherapy. New research from the University of Pittsburgh and UPMC Hillman Cancer Center found that a type of drug called peripherally restricted OPRM1 antagonists (PAMORAs) blocked opioid-induced...
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Why cancer immunotherapies don’t work for everyone
by Katherine Egan Bennett, University of Texas at Arlington Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113516A multi-institutional study co-authored by University of Texas at Arlington scientists uncovered a mechanism by which cancer cells prevent the immune system from activating and attacking the cancerous invaders. The study, published in Cell Reports, sheds light on why immunotherapy treatments don’t...
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Researchers synthesize chimeric peptide that elicits antitumor activity for cancer immunotherapy
by Science China Press The peptide Pal-DMPOP consists a peptide inhibitor of CD47/SIRPα, a D-peptide inhibitor of PD-1/PD-L1, and a palmitic acid tail conjugated at its N-terminal through a PEG4 linker. This design made this peptide resistant to serum proteolysis and accumulated in the tumor tissues. It can block CD47/SIRPα and PD-1/PD-L1 to enhance the phagocytosis...
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Study hints at how cancer immunotherapy can be safer
YALE UNIVERSITY New Haven, Conn. — Cancer immunotherapy has revolutionized treatment of many forms of cancer by unleashing the immune system response against tumors. Immunotherapies that block checkpoint receptors like PD-1, proteins that limit the capacity of T cells to attack tumors, have become the choice for the treatment of numerous types of solid cancer. However,...
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New computational tool identifies novel targets for cancer immunotherapy
CHILDREN’S HOSPITAL OF PHILADELPHIA Philadelphia, May 17, 2023—Researchers at Children’s Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets. The tool, called “Isoform peptides from RNA splicing for Immunotherapy target Screening”...
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Can lymph nodes boost the success of cancer immunotherapy?
Graphical abstract. Credit: Cell (2023). DOI: 10.1016/j.cell.2023.02.021 Cancer treatment routinely involves taking out lymph nodes near the tumor in case they contain metastatic cancer cells. But new findings from a clinical trial by researchers at UC San Francisco and Gladstone Institutes shows that immunotherapy can activate tumor-fighting T cells in nearby lymph nodes. The study, published in...
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Bioengineers combine lab-on-a-chip technology with AI to improve cancer immunotherapy
by Indiana University The platform tracks T cell infiltration of tumor spheroids, which are 3D structures made of cancer cells. Credit: Feng Guo An interdisciplinary team of researchers led by Indiana University bioengineer Feng Guo has developed a tool that could lead to improved cancer immunotherapy. The prototype platform facilitates automated drug screening and real-time,...
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Predicting cancer immunotherapy response from gut microbiomes using machine learning models
by Impact Journals LLC Comparisons of gut microbiome between responders and non-responders from the combined dataset. Credit: Liang et al, Oncotarget (2022). DOI: 10.18632/oncotarget.28252 A new research paper was published in Oncotarget on July 19, 2022, titled “Predicting cancer immunotherapy response from gut microbiomes using machine learning models.” Cancer immunotherapy has significantly improved patient survival. Yet half of patients do not...
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Discovery could lead to better cancer immunotherapy
Washington State University Credit: Unsplash/CC0 Public Domain A type of white blood cell previously known only as a helper in the immune system appears also to be the instigator of the body’s defenses against cancerous tumors. The discovery could lead to more effective cancer immunotherapy, a promising treatment which uses the body’s own immune system,...