Peer-Reviewed Publication COLD SPRING HARBOR LABORATORY Spinal muscular atrophy, or SMA, is the leading genetic cause of infant death. Less than a decade ago, Cold Spring Harbor Laboratory (CSHL) Professor Adrian Krainer showed this brutal disease can be treated by tweaking a process called RNA splicing. This breakthrough resulted in Spinraza, the first effective treatment...
Tag: <span>working</span>
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Scientists gain new insights into how small intestine works
by Ernie Mundell It was the ancient Greeks who first divided the 20-foot length of the small intestine into three parts: The duodenum, the jejunum and the ileum. However, the organ may finally be ready for an update: U.S. researchers say the small intestine is actually comprised of five distinct segments, each being responsible for...
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Why Do GLP-1 Drugs Stop Working, and What to Do About It?
There’s no question that glucagon-like peptide 1 (GLP-1) agonists represent a major advance in the treatment of obesity for patients with or without diabetes. In clinical trials, participants lost 15%-20% of their body weight, depending on the drug. But studies also have shown that once people stop taking these drugs — either by choice, because...
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Why cancer immunotherapies don’t work for everyone
by Katherine Egan Bennett, University of Texas at Arlington Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113516A multi-institutional study co-authored by University of Texas at Arlington scientists uncovered a mechanism by which cancer cells prevent the immune system from activating and attacking the cancerous invaders. The study, published in Cell Reports, sheds light on why immunotherapy treatments don’t...
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Why weight loss drugs stop working and how to break past the Ozempic plateau
After using Ozempic for a while, many people may reach a plateau with their weight loss progress. Jaap Arriens/NurPhoto via Getty ImagesDrugs such as Ozempic and Wegovy eventually reach a weight loss plateau, beyond which further weight loss slows or stops.Like any other healthy weight loss method, the body eventually settles at an appropriate weight,...
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HOW TO AVOID ACHY FEET WHILE WORKING AT HOME
Sean Peden, an orthopaedic foot and ankle specialist from Yale University Medicine, says not wearing supportive footwear on a regular basis can lead to foot pain and other problems. “Many people are continuing to work at home part- or full-time, which for some can mean wearing slippers or walking around barefoot,” Peden says. “And because...